CARASIL image from New Medical Terms



Definition An autosomal recessive condition (OMIM:600142) characterised by non-hypertensive arteriopathy of cerebral small vessels with subcortical infarcts, alopecia, and spondylosis.

Micro, small cerebral arteries Arteriosclerosis, fibrous intimal proliferation, and hyaline degeneration with splitting of intima and/or internal elastic membrane.

Neurologic features Progressive dementia, gait disturbances, extrapyramidal and pyramidal signs, demyelination of cerebral white matter with sparing of U fibres.

Molecular pathology Defects of HTRA1, which encodes a serine protease that is thought to regulate the availability of insulin-like growth factors–IGFs, cause CARASIL. 

Synonyms Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy—autosomal recessive, cerebrovascular disases with thin skin—alopecia—and disc disease, MAEDA syndrome, subcortical vascular encephalopathy—progressive 

The famed Carousel, with its calliope music and 57 horses, is one of Central Park’s most popular attractions. It is said that a live mule hidden beneath the Carousel platform, powered the original from 1873 until 1924. The animals were taught to start and stop when the operator tapped on the floor. The next two carousels were destroyed by fire, the first in 1924 and its successor in 1950. The Parks Department discovered the pictured vintage carousel abandoned in an old trolley terminal on Coney Island. It is one of the largest carousels in the US and finest example of American folk art.



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