atrial fibrillation—familial—4

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atrial fibrillation—familial—42016-11-24T20:47:13+00:00

atrial fibrillation—familial—4

CARDIOLOGY

A genetic variant (OMIM:611493) of atrial fibrillation* caused by defects in a voltage-gated potassium channel.

*A cardiac arrhythmia characterised by disorganised atrial electrical activity and ineffective atrial contraction, resulting in blood stasis in the atria and reduced ventricular filling, which can cause palpitations, syncope, thromboembolic stroke, and congestive heart failure.

Molecular pathology Defects of KCNE2, which encodes a voltage-gated potassium channel, cause atrial fibrillation—familial—4. 

References http://www.uniprot.org/uniprot/Q9Y6J6 

http://www.omim.org/entry/611493

 

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