parietal foramina

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parietal foramina2016-11-27T16:16:41+00:00

parietal foramina

parietal foramina image from New Medical Terms

large parietal foramina superior and slightly medial to the orbits

IMAGING, PAEDIATRICS

An autosomal dominant condition (OMIM:168500) characterised by large oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated at the 5th fetal month.  

Molecular pathology Defects of:

MSX2—which encodes a transcription repressor that ensures a balance between survival and apoptosis of neural crest-derived cells required for craniofacial morphogenesis, that also plays a role in limb-pattern formation, cause parietal foramina 1 (PF1).

ALX4—which encodes a homeodomain transcription factor that may play a role in craniofacial development, cause PF2. 

Synonyms Catlin marks, foramina parietalia permagna, PF—symmetric, PFM

References http://www.uniprot.org/uniprot/P35548

http://www.omim.org/entry/168500

image from European Journal of Human Genetics (2006) 14, 151–158. doi:10.1038/sj.ejhg.5201526

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