temperature-sensitive folding

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temperature-sensitive folding2016-05-27T21:15:54+00:00

temperature-sensitive folding


A self-explanatory term referring to the changes in the conformation of a protein or other biomolecule in three-dimensional space, which will affect how well it will bind to its cognate ligand.

Low molecular weight compounds have the potential for correcting temperature folding defects that result in human disease–e.g., the folding defect associated with the DF508 cystic fibrosis transmembrane regulator (CFTR) protein.

Reference J Clin Invest. Mar 15, 1997; 99(6): 1432–1444.doi:  10.1172/JCI119302

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