Schaffer collateral pathway
A pathway of axon collaterals given off by CA3 pyramidal cells in the hippocampus which project to area CA1 of the hippocampus and are integral to memory formation, to the emotional network of the Papez circuit, and to the hippocampal trisynaptic loop. The Schaffer collateral is integral to activity-dependent synaptic plasticity and information processing through the hippocampus, and is the construct of long-term potentiation in which some synapses grow stronger and others weaken over time.
It is named after the Hungarian anatomist-neurologist Károly Schaffer.
Synonyms Schaffer collateral-ca1 pathway, Schaffer collateral commissural pathway, Schaffer collateral fiber pathway