perforant pathway

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perforant pathway2016-11-15T20:30:30+00:00

perforant pathway

perforant pathway image from New Medical Terms

schematic of perforant pathway


One of three major pathways in the hippocampus that plays a role in long-term potentiation (memory), which projects from the entorhinal cortex to the granule cells of the dentate gyrus.

Like the other two hippocampus pathways*, it is sensitive to previous activation, e.g., a brief train of high frequency stimuli increases the amplitude of the excitatory postsynaptic potential–EPSPs in target hippocampal neurons. 

*The mossy fibre pathway and the Schaffer collateral pathway


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