endocannabinoid signaling pathway
MOLECULAR MEDICINE, NEUROLOGY, PHYSIOLOGY
An endogenous pathway which regulates a wide range of processes such as neurotransmission, mood, appetite, pain sensation, inflammation and memory, and evokes marijuana-like behavioural effects.
The endocannabinoid system consists of three components:
• Endogenous cannabinoids–anandamide and 2-AG, both of which are THC/marijuana-like chemicals
• Enzymes that regulate the biosynthesis and breakdown of these endogenous cannabinoids
• Receptors that are activated by anandamide and 2-AG, as well as the primary active ingredient in marijuana, THC.
The system modulates key processes and responses, including pain, cognitive processes, anxiety, feeding, lipid synthesis, epilepsy, and inflammation in the brain, GI tract and periphery.
Molecular pathology Defects of ABHD6 cause PHARC (polyneuropathy—hearing loss—ataxia—retinitis pigmentosa—cataract, OMIM:612674), a neurodegenerative disease due to an inborn error of endocannabinoid metabolism