GENETICS
A meiosis-specific, multimeric protein complex required for the cohesion of sister chromatids after DNA replication, which forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
The complex is thought to replace the mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
References http://www.genecards.org/cgi-bin/carddisp.pl?gene=STAG3
http://www.uniprot.org/uniprot/Q9UJ98
Image from http://www.nature.com/nature/journal/v467/n7314/images/467406a-f1.2.jpg
Leave A Comment
You must be logged in to post a comment.