poor metaboliser

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poor metaboliser2016-11-15T21:17:30+00:00

poor metaboliser 

PHARMACOLOGY, PHYSIOLOGY

A person who metabolises a probe drug–the rate of which is related to the metabolising cytochrome P-450 enzyme–slower than others; a person can be a poor metaboliser of one probe drug, and an extensive metaboliser of another.

Examples, poor metaboliser genes

• CYP2C19–which metabolises xenobiotics, including mephenytoin, omeprazole, diazepam, proguanil, propranolol, citalopram, imipramine and some barbiturates

• CYP2D6–which metabolises environmental chemicals and up to 20% of commonly prescribed drugs, including antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.

Frequency, poor metabolisers 2-5% of Caucasians; 13-23% of Asians, 38-79% of Polynesian and Micronesian islanders. 

Reference http://www.uniprot.org/uniprot/P33261

 

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