nivolumab

nivolumab2016-12-25T08:26:05+00:00

nivolumab

IMMUNOLOGY

A fully human IgG4 antibody which blocks the programmed cell death 1 receptor encoded by PDCD1 on chromosome 2q37.3, resulting in objective clinical responses to advanced melanoma, renal cell carcinoma, and non-small cell carcinoma, presumably by contributing to T cell exhaustion in peripheral tissues. 

Also known as BMS-936558, MDX1106

References http://en.wikipedia.org/wiki/Nivolumab
N Engl J Med 2013; 369:122-133  

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