CELL BIOLOGY, PHYSIOLOGY
A biochemical mechanism found in living systems which oscillates with a period of 24 hours and is coordinated with the day-night cycle. Oscillator proteins are ubiquitous in tissues, where they are synchronised by both endogenous and external signals to regulate transcriptional activity throughout the day in a tissue-specific manner.
Mechanisms of circadian oscillator regulation Phosphorylation, SUMOylation, ubiquitination, histone acetylation and deacetylation
Circadian oscillators CRYs, CK1s—CSNK1D, CSNK1E; PERs—–PER1, PER2, PER3
Diabetologia. 2013 Mar;56(3):497-507. doi: 10.1007/s00125-012-2779-7