changrolin

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changrolin2016-12-31T07:16:41+00:00

changrolin 

changrolin from Dichroa febrifuga image from New Medical Terms

Dichroa febrifuga, which produces changrolin

PHARMACOGNOSY

An anti-arrhythmic drug derived from beta-dichroine, an active component of the Chinese medicinal herbDichroa febrifuga Lour (image), which acts by blocking Na+–especially in the inactivated state and Ca2+ channels. It also partially blocks K+ channels (Ito and IK).

Chemical name 2,6-bis[pyrrolidin-1-ylmethyl]-4-[quinazolin-4-ylamino] phenol 

Reference Eur J Pharmacol. 2010 Nov 25;647(1-3):139-46

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