childhood disintegrative disorder

PAEDIATRIC NEUROLOGY

An uncommon–1.7/10⁵–idiopathic condition affecting children which is characterised by normal development followed by a deterioration of developmental milestones in language, social function, and motor skills.
Note: Childhood disintegrateive disorder is included in the American Psychiatriac Association’s DSM-5 under the umbrella term of autism spectrum disorder.

Case-defining features: 2 of the following 6 functional areas:

• Expressive language skills

• Language comprehension

• Social skills

• Self care

• Bowel and bladder control

• Play skills

• Motor skills

Impairment in 2+ of the following 3 areas:

• Social interaction

• Communication

• Repetitive behaviour & interests

Aetiology Unknown; may be associated with lipid storage diseases, subacute sclerosing panencephalitis, tuberous sclerosis

Management As for autism: behaviour therapy, environmental (sensory enrichment) therapy, medications–e.g., antipsychotics, anticonvulsants

Synonyms Dementia infantilis, disintegrative psychosis, Heller syndrome 

Reference https://en.wikipedia.org/wiki/Childhood_disintegrative_disorder

http://www.dsm5.org/documents/changes%20from%20dsm-iv-tr%20to%20dsm-5.pdf