smudge cell

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smudge cell2016-11-14T05:17:48+00:00

smudge cell

smudge cell image from New Medical Terms

high power Wright stained peripheral smear with smudge cell

HAEMATOLOGY

Definition A term of art for red-purple nuclear debris with clumped chromatin and rounded nucleolar remnants, which correspond to degenerated lymphocytes of acute lymphoblastic leukaemia–ALL or chronic lymphocytic leukaemia–CLL (see image), and nucleated red cells. 

LIVER PATHOLOGY

Definition An enlarged basophilic hepatocyte replete with adenovirus particles

LUNG PATHOLOGY

Definition Diffusely basophilic, streaked CMV-infected–or less commonly, adenovirus infected–alveolar and bronchial cells with indistinct nuclear:cytoplasmic interface due to vacuolisation of nuclear membrane

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