signet ring cell

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signet ring cell2016-11-14T04:38:55+00:00

signet ring cell 

signet ring image from New Medical Terms

signet ring


Definition A usually malignant cell containing copious clear cytoplasm that flattens a hyperchromatic nucleus to one side, having an appearance likened to a signet ring.

Cancers composed predominantly of signet ring cells often carry a worse prognosis; the “classic”–and most common–signet ring cells occur in the stomach, but are well described in carcinoma of the breast, colon, gallbladder, lung, nasal cavity, prostate, thyroid—medullary 

signet ring cell adenocarcinoma image from New Medical Terms

signet ring cell adenocarcinoma

carcinoma and urinary bladder. Malignant signet ring cells may also be seen in non-epithelial malignancies–e.g., mesothelioma, rhabdomyosarcoma, balloon cell melanoma, oligodendroglioma, myxoid angioblastomatosis, myxoid liposarcoma, lymphoma, and is a morphology typical of normal fat cells, oligodendrogliocytes and muciphages.


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