Definition A relatively rare—0.06% at one institution—complication of therapeutic radiation with a mean latency of 15 years, in which a soft-tissue malignancy arises in the irradiated field.
Histology Osteosarcoma (image), fibrosarcoma; all high-grade
Prognosis 85% 1-year survival; 45% 5-year survival
Synonym Post-irradiation sarcoma
Reference J Surg Oncol. 2012 May;105(6):570-6.
doi: 10.1002/jso.22122. Epub 2011 Oct 19