metastasising pleomorphic adenoma

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metastasising pleomorphic adenoma2016-11-13T17:49:09+00:00

metastasising pleomorphic adenoma 

metastasising pleomorphic adenoma image from New Medical Terms

Low power H&E stained image of metastasising pleomorphic adenoma


An über rare–circa 60 cases reported in the world literature–salivary gland tumour, which is one of 3 different patterns of malignant change–the other 2 are carcinoma ex pleomorphic adenoma–PA and true malignant mixed tumor (carcinosarcoma)–that occur in PA.

Diagnostic criteria One or more foci of metastatic histologically benign PA, accompanied by a current PA of major or minor salivary gland origin, or a history of previously surgerised PA

Aetiology Uncertain; usually there is a history of a recurrent and/or incompletely excised PA

Metastases Haematogenous or lymphatic spread to bone, head and neck, lungs, and elsewhere–skin, liver, retroperitoneum, kidney, lymph nodes, and CNS

Mortality 20-43% of patients die of disease 

Synonyms Benign metastasising pleomorphic adenoma, metastasising benign mixed adenoma, metastasising mixed tumour, metastasising pleomorphic mixed tumour 

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