medial calcific sclerosis

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medial calcific sclerosis2016-11-13T17:39:27+00:00

medial calcific sclerosis

medial calcific sclerosis image from New Medical Terms

plain film of major vessel with medial calcific sclerosis


A type of dystrophic calcification in which calcium is deposited in the tunica media of arteries.

Clinical findings Medial cystic sclerosis is usually asymptomatic, but may be associated with atherosclerosis, hypertension, diabetes, and chronic kidney disease. Areas affected are “pulseless” due to the calcified encasement; areas beyond the sclerosis have a “bounding pulses”.

Imaging Affected medium-sized arteries in the upper and lower limbs have linear

medial calcific sclerosis image from New Medical Terms

low power H&E stained cross section of artery with medial calcific sclerosis

calcifications, resulting in a so-called pipestem appearance. 

Pathogenesis Uncertain; an array of calcium regulating proteins have been implicated, including osteopontin, osteoprotegerin, matrix GLA protein, fetuin-A, receptor activator of NF-kappa-B, receptor activator of NF-kappa-B ligand and TNF-related apoptosis-inducing ligand. 

Synonyms Arterial concretion, medial arteriosclerosis, medial calcification, medial calcified arteriosclerosis, medial calcified sclerosis, Mönckeberg atherosclerosis, Mönckeberg’s disease 


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