A descriptive term for a histologic feature of Bowen’s disease as well as adnexal carcinoma of the skin, in which extensive intraepidermal pagetoid spread of sheets of atypical cells which are concentrated at the suprabasal layer, the appearance of which has been fancifully likened to the
sharp demarcation of eyeliner. The sign is accompanied by intercellular bridging,
focal/non-uniform CK7 staining, negative CEA and mucicarmine staining, and marked solar elastosis.
Color Atlas of Dermatopathology, JM Grant-Kels
Essentials of Anatomic Pathology L Cheng, DG Bostwick