dysembryoplastic neuroepithelial tumour

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dysembryoplastic neuroepithelial tumour2016-11-25T18:54:07+00:00

dysembryoplastic neuroepithelial tumour

dysembryoplastic neuroepithelial tumour H&E image from New Medical Terms

medium power H&E stained section of dysembryoplastic neuroepithelial tumour

PATHOLOGY 

A usually well-circumscribed* supratentorial low-grade glial tumour (WHO grade 1) that presents in childhood with seizures.

*Diffuse forms have been described

Clinical findings Headache, nausea, vomiting, visual disturbances

Imaging Lesions are lobular, well-

CT of dysembryoplastic neuroepithelial tumour image from New Medical Terms

CT of dysembryoplastic neuroepithelial tumour

delineated, hypointense on T1-weighted MRI and hyperintense on T2; they are uniformly non-enhancing or showed minimal peripheral enhancement; they lack surrounding oedema; a few enhance with contrast.

Management Surgery

Prognosis While DNET rarely recurs after resection, residual tumour is a major risk factor for future partial complex seizures, which occur in up to 35% of cases.

References Neuropathol Appl Neurobiol. 2012 Aug;38(5):411-25.

doi: 10.1111/j.1365-2990.2011.01225.x

radiopaedia.org/cases/dysembryoplastic-neuroepithelial-tumour-dnet

http://www.medscape.com/viewarticle/507324

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