brown stain

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brown stain2016-11-13T22:15:01+00:00

brown stain

brown stain image from New Medical Terms

brown stain (immunohistochemical stain) for vimentin


A term of art used by histopathologists for an immunoperoxidase stain used to detect antigens–e.g., vimentin (image), leukocyte common antigen, cytokeratin, S-100, etc. in tissues by linking monoclonal antibodies raised against the antigen of interest to an enzyme in the last of several antigen-antibody steps. If antigen X is present, the enzyme digests a colourless substrate into a brown coloured product. 


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