blue cell tumour
A usually malignant tumour, the cells of which are arranged in nests and sheets of relatively monotonous, round to oval, 8-15 µm in diameter cells with poorly defined cytoplasmic borders and strongly basophilic–blue by H&E staining nuclei.
Determining the tumour’s embryonic origin often requires ancillary information provided by histologic pattern, immunohistochemistry, and rarely electron microscopy.
Differential diagnosis, blue cell tumours
• Children Neuroblastoma, Ewing sarcoma, non-Hodgkin lymphoma–NHL, embryonal rhabdomyosarcoma, medulloblastoma (see image)
• Adults Neuroendocrine tumour, mesenchymal chondrosarcoma, hemangiopericytoma, large cell lymphomas, Merkel cell tumour, small cell osteosarcoma, small/oat cell carcinoma, alveolar rhabdomyosarcoma