A rare histologic variant of leiomyoma, which most commonly occurs in the uterus, but may also be seen in the prostate, nasal cavity and elsewhere, which behaves in a completely benign fashion, despite seriously worrisome histologic features
Histopathology Spindled bizarre, giant, pleomorphic cells with eosinophilic cytoplasm and blunt-ended nuclei in a prominent myxoid background. The key to the diagnosis of benignancy is the low mitotic activity and demonstration of euploidy. When compared to uterine leiomyosarcoma (LMS), expression rates of ER and PR and number of mast cells are significantly lower in LMS, while the expression of PCNA in LMS is higher.
Synonym Symplastic leiomyoma
Reference Intl J Gynecology & Obstetrics, 2008; 102:296-297