osteoarthritis susceptibility 5

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osteoarthritis susceptibility 52016-11-27T15:56:18+00:00

osteoarthritis susceptibility 5


A degenerative joint disease, osteoarthritis—susceptibility to—5 (OMIM:612400) characterised by deterioration of hyaline articular cartilage, remodelling of subchondral bone and osteosclerosis.

Clinical findings Pain and joint stiffness often leading to significant disability and need for joint replacement.

Molecular pathology Defects of GDF5, which encodes a protein thought to be involved in bone and cartilage formation, are linked to osteoarthritis 5—susceptibility to.

Synonym Osteoarthritis of hip  

References http://www.genecards.org/cgi-bin/carddisp.pl?gene=GDF5



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