A condition linked to the use of nitrogen-containing bisphosphonate drugs, resulting in osteonecrosis of the jaw.

Drugs implicated Zoledronate, pamidronate, or combination thereof, which are used to to prevent skeletal fractures in patients with osteophilic malignancies—e.g., myeloma, breast and prostate cancers. About 5% of those with BIONJ are being treated for osteoporosis

Risk factors Tooth extractions–50% of cases, mandibular exostoses, periodontal disease, trauma from ill-fitting dentures, smoking, obesity, use of cytotoxic drugs and glucocorticoids

Synonym Bisphosphonate-induced osteonecrosis of the jaw

References‘Phossy-Jaw’Reid IR.

Bone 2008; doi: 10.1016/j.bone.2008.09.012

Sedghizadeh PP, et al. J Am Dent Assoc 2009; 140: 61-66

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