corneal dystrophy—congenital stromal

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corneal dystrophy—congenital stromal2016-11-28T21:37:38+00:00

corneal dystrophy—congenital stromal 

OPHTHALMOLOGY

A usually autosomal dominant condition (OMIM:610048) characterised by bilateral, primary alterations of the cornea unassociated with prior inflammation or systemic disease.

Molecular pathology Defects of DCN, which encodes decorin, a connective tissue proteoglycan that binds to type I collagen fibrils, and plays a role in matrix assembly, cause congenital stromal corneal dystrophy. 

References http://www.uniprot.org/uniprot/P07585

http://www.omim.org/entry/610048

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