premature ovarian failure 2A

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premature ovarian failure 2A2016-11-27T20:38:52+00:00

premature ovarian failure 2A

REPRODUCTION

Definition Premature ovarian failure 2A is an ovarian disorder (OMIM:300511) defined as the cessation of ovarian function under age 40, with oligomenorrhoea or amenorrhoea, elevated serum gonadotropins and low oestradiol

Molecular pathology Defects of DIAPH2, which encodes a homolog of the Drosophila diaphanous gene that is thought to play a role in the development and normal function of the ovaries, cause premature ovarian failure 2A.

References http://www.uniprot.org/uniprot/O60879

http://www.omim.org/entry/300511

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