Definition A general term for a state of sleep inadequacy at the appropriate time, which may be acute or chronic.
CNS effects of sleep deprivation
• Reduced functional connectivity between the posterior cingulate cortex and the anterior cingulate cortices.
• Increased functional connectivity between the dorsal nexus* and specific areas of the right dorsolateral preforntal cortex.
*An area of the brain thought to play a central role in the pathophysiology of depression. Both of these effects are thought to shift the brain’s resting state connectivity from predominately affective–read, rumination, negative anticipation and sense of guilt and/or shame, to improved cognitive control.
Therapeutic sleep deprivation (SD) Intentionally depriving individuals of sleep has been used as a therapeutic strategy for major depression.
Well-known cases SSD was blamed for the
• Near meltdown of the Three Mile Island nuclear power plant–1979
• Explosion of the space shuttle Challenger–1986,
• Exxon Valdez oil spill–1989.
Reference Proc Natl Acad Sci 110, 19597 (2013), in Science