herpes simplex encephalitis—susceptibility to—4

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herpes simplex encephalitis—susceptibility to—42016-11-26T02:23:17+00:00

herpes simplex encephalitis—susceptibility to—4

NEUROLOGY, VIROLOGY

A rare complication of human herpesvirus 1–HHV-1 infection, which affects genetically susceptible (OMIM:614850) individuals

Clinical findings Onset develops over several days with fever, headache, seizures, stupor, and coma; it is often fatal. 

Pathology Patchy haemorrhagic necrosis of temporal and frontal lobes.

Molecular pathology Defects of TICAM1, which encodes an adaptor protein involved in innate (native) immunity against invasive pathogens, causes herpes simplex encephalitis—susceptibility to—4. 

Synonym Encephalopathy—acute—infection-induced—susceptibility to—6

References http://www.uniprot.org/uniprot/Q8IUC6

http://www.omim.org/entry/614850

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