chronic traumatic encephalopathy
NEUROLOGY, SPORTS MEDICINE
A progressive neurodegenerative disease that is a long-term consequence of single or repetitive closed head injury, which occurs in those who have been subjected to multiple concussions while participating in football (American football as well as association football), rugby, ice hockey, professional wrestling and other contact sports.
The term was introduced as a clinicopathological construct to distinguish the sequelae of these sports from the late effects of boxing.
Clinical findings Dementia, memory loss, aggression, confusion and depression that appear from months to decades after the “sub-concussions”
Micro Brain degeneration and accumulation of tau protein
Synonyms Traumatic brain disease, traumatic brain lesion
Text taken verbatim from Boston University reference (below)
In both sets of photographs, above, the brain tissue has been immunostained for tau protein, which appears as a dark brown color. Tau immunostained sections of medial temporal lobe from 3 individuals
- Top left: Whole brain section from a 65 year old control subject showing no tau protein deposition
- Bottom left: Microscopic section from 65 year old control subject also shows no tau protein deposition
- Top middle: Whole brain section from John Grimsley showing abundant tau protein deposition in the amygdala and adjacent temporal cortex
- Bottom middle: Microscopic section showing numerous tau positive neurofibrillary tangles and neurites in the amygdala
- Top right: Whole brain section from a 73 year old world champion boxer with severe dementia showing very severe tau protein deposition in the amygdala and thalamus
- Bottom right: Microscopic section from a 73 year old world champion boxer with severe dementia showing extremely dense tau positive neurofibrillary tangles and neurites in the amygdala