risk-reducing salpingooophorectomy

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risk-reducing salpingooophorectomy2016-11-12T02:08:19+00:00

risk-reducing salpingooophorectomy 


A self-explanatory term for the elective removal of the fallopian tubes and ovaries in women with the BRCA1 or BRCA2 mutation, which carries an increased risk of developing cancers in those tissues.

In one study, invasive or intraepithelial ovarian/tubal/peritoneal neoplasms were detected in 2.6% of 966 RRSOs (BRCA1 mutation carriers, 4.6%; BRCA2 carriers, 3.5%; and noncarriers, 0.5%). Positive BRCA1/2 mutation status, postmenopausal status, and abnormal CA-125 levels and/or positive transvaginal ultrasound examinations were associated with detection of clinically occult neoplasms at RRSO. For women with negative BRCA1/2 mutations and normal CA-125 levels had no malignant changes in excised tissue. 

Synonym Prophylactic salpingo-oophorectomy (both terms are in active use) 

Reference doi: 10.1200/JCO.2013.54.1987J Clin Oncology, Sept 8, 2014, ME Sherman et al

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