chemical carcinogenesisJoe Segen2017-01-02T13:36:39+00:00
A multi-step process in which a malignancy is induced by one or more carcinogenic chemicals, which can be:
• Occupational–e.g., aromatic amines, arsenic, benzene, cadmium, chromium ores, soots, tars, vinyl chloride
• Environmental–e.g., aflatoxin, asbestos, nitrites, sunlight, tobacco, or
• Iatrogenic—e.g., alkylating agents used to manage cancer, anabolic steroids, phenacetin.
Pathogenesis Initiation of the carcinogenic cascade occurs when an electrophilically reactive chemical–initiator, or more often one or more of its metabolites, interacts with DNA, and repair of the damaged DNA is unsuccessful.
Chemical carcinogenesis may be followed by a sequence known as tumour promotion.
Reference Semin Cancer Biol. 2004 Dec;14(6):473-86