non-alcoholic fatty liver disease

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non-alcoholic fatty liver disease2017-01-13T00:57:53+00:00

non-alcoholic fatty liver disease 

HEPATOLOGY

A hepatopathy that is the most common form of liver disease in Western countries and characterised by accumulation of triglycerides in the liver and dysmetabolism in the form of insulin resistance and dyslipidemia. NAFLD encompasses a range of liver disease from simple fat accumulation (steatosis) which may evoke an inflammatory response in the liver, referred to as steatohepatitis, that can progress to cirrhosis and hepatocellular carcinoma (liver cancer).

Pathology Steatosis, sinusoidal fibrosis, perivenular fibrosis, ballooning degeneration, and nuclear vacuolisation

Disease progression
• Steatosis
• Steatosis with inflammation (non-alcoholic steatohepatitis–NASH)
• Cirrhosis

Fatty liver disease—nonalcoholic—susceptibility to types
• Fatty liver disease—nonalcoholic—susceptibility to—1 (OMIM:613282) PNPLA3
• Fatty liver disease—nonalcoholic—susceptibility to—2 (OMIM:613387) APOC3 .

Synonyms NAFLD, non-alcoholic fatty liver disease 

Reference http://omim.org/entry/613282
http://www.uniprot.org/uniprot/Q9NST1