somatostatinoma syndromeJoe Segen2016-11-08T21:17:23+00:00
An über rare paraneoplastic syndrome caused by ectopic somatostatin secretion, often from a malignant neuroendocrine tumour located at the head of the pancreas.
Clinical findings Vomiting, hypochlorhydria and achlorhydria, abdominal pain, diarrhoea, malabsorption, weight loss, cholelithiasis, poor glucose control, causing secondary diabetes mellitus, steatorrhoea, anaemia
Laboratory Increased somatostatin, which evokes a reactive reduction in insulin, glucagon, and gastrin.
Management Surgical resection, chemotherapy with 5-FU and doxorubicin