exercise-induced hyperinsulinaemic hypoglycaemia

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exercise-induced hyperinsulinaemic hypoglycaemia2016-11-25T19:56:34+00:00

exercise-induced hyperinsulinaemic hypoglycaemia

ENDOCRINOLOGY, METABOLISM

Definition An autosomal dominant hypoglycaemic disorder (OMIM:245340), characterised by inappropriate insulin secretion during anaerobic exercise or after pyruvate loading.

Molecular pathology Defects of SLC16A1, which encodes a proton-coupled transporter that catalyses the movement of monocarboxylates–e.g., lactate and pyruvate, and ketone bodies across the plasma membrane, cause exercise-induced hyperinsulinaemic hypoglycaemia. 

Synonyms Familial hyperinsulinaemic hypoglycaemia type 7 

References http://www.uniprot.org/uniprot/P53985

http://www.omim.org/entry/610021

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