clipase

clipase2016-11-08T17:59:00+00:00

clipase

ENDOCRINOLOGY

Definition A popular term for any of several intracellular proteolytic enzymes that remove pre- and pro- portions of a hormone.

Example PTH, a 25-residue polypeptide is “clipped” from the 115-residue pre-pro-parent, yielding a 90-residue pre-PTH; a 6-residue segment is then removed by tryptic clipase from the pre-PTH, yielding mature 84-residue PTH. 

Reference http://faculty.ksu.edu.sa/52876/Postgraduate%20lecture/Calciotropic_Hormones.pdf

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