retinoic acid embryopathy

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retinoic acid embryopathy2016-11-27T21:58:05+00:00

retinoic acid embryopathy 

EMBRYOLOGY, NEONATOLOGY

Definition A teratogenic disease complex induced by retinoic acid, a vitamin A analogue, resulting in a 26-fold increase in congenital defects–e.g., microtia, anotia, cleft palate, cardiac–conotruncal and aortic arch, neural crest, craniofacial, thymic defects, hyperostoses, retinal and optic nerve abnormalities, CNS malformations, premature closure of the epiphyseal plates.

Comment An identical embryopathy has been described with megadose ingestion of vitamin A during pregnancy. 

Synonym Accutane embryopathy

Reference http://www.nejm.org/doi/full/10.1056/NEJM198510033131401

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