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Groucho/TLE/Grg familyJoe Segen2017-01-03T16:00:32+00:00
A family of transcriptional co-repressors, of which the protein Groucho* was the founding member. Gro family proteins are broadly expressed during development and in adults, shouldering essential functions in various developmental pathways–e.g., Notch and Wnt signaling, and have been implicated in the pathogenesis of some cancers. Gro proteins have different modes of action depending on context and modify chromatin structure at target genes.
First identified in Drosophila melanogaster, the family now includes the transducin-like enhancer of split—TLE and Gro-related gene—Grg proteins in vertebrates. Gro family proteins don’t bind DNA directly, but are recruited by various transcription factors, including members of the Hes, Runx, Nkx, LEF1/Tcf, Pax, Six and c-Myc families.
Groucho was named after the phenotype of the first identified mutation in the Groucho/TLE/Grg family: gro1 mutant Drosophila melanogaster. It displays clumps of extra bristles above the adult eyes which were fancifully likened to the distinctive eyebrows of American comedian Groucho Marx (as drawn by Al Hirschfeld).
Reference Genome Biology 2008, 9:205 doi:10.1186/gb-2008-9-1-205