caudal duplication anomaly

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caudal duplication anomaly2016-11-25T07:15:01+00:00

caudal duplication anomaly 

EMBRYOLOGY, MOLECULAR MEDICINE

An inherited condition (OMIM:607864) characterised by duplications of different issues and organs–e.g., distal spine from L4, ureter, vagina and cervix, and distal colon, in the caudal region of the body.

Molecular pathology Hypermethylation of AXIN1, which encodes a cytoplasmic protein that modulates Wnt-signaling and controls cell growth, apoptosis and development, cause caudal duplication anomaly. 

References http://www.uniprot.org/uniprot/O15169

http://omim.org/entry/607864

 

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