solitary median maxillary central incisor

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solitary median maxillary central incisor2016-11-28T04:15:54+00:00

solitary median maxillary central incisor

DENTISTRY

Definition A rare dental anomaly (OMIM:147250) characterised by the congenital absence of one maxillary central incisor

Molecular pathology Defects in SHH, which encodes Sonic Hedgehog, a protein central to early embryonic patterning for the anterior-posterior limb axis, the ventral somites and ventral neural tube, cause solitary median maxillary central incisor.

Synonyms Fused incisors, incisors—fused, single central maxillary incisor, single upper central incisor, SMMCI syndrome

Reference http://www.omim.org/entry/147250 

http://www.uniprot.org/uniprot/Q15465

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