histatin

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histatin2016-11-08T12:55:02+00:00

histatin

DENTISTRY, ENT

Definition Any of a number of salivary proteins which are major precursors of the enamel pellicle, a protective proteinaceous layer on tooth surfaces. In addition, histatins exhibit antibacterial and antifungal activity. His3-(20-43)-peptide (histatin-5) is effective against Candida albicans and C neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from Porphyromonas gingivalis. His3-(20-43)-peptide is also a potent inhibitor of metalloproteinases MMP2 and MMP9. 

References http://www.genecards.org/cgi-bin/carddisp.pl?gene=HTN3

http://www.uniprot.org/uniprot/P15516

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