Any of 3 trypsin-like cysteine proteinases–rgpA, rgpB, and kgp produced by Porphyromonas gingivalis, a bug seen in adult periodontitis. Gingipains degrade macrophage CD14, inhibiting leukocyte activation via the lipopolysaccharide (LPS) receptor, thereby facilitating sustained oral colonisation of P gingivalis. Gingipains are linked to the development of periodontitis.
Reference J Periodontol. 2003 Jan;74(1):111-8