failure of tooth eruption—primary 

DENTISTRY

A rare autosomal dominant disorder (OMIM:125350) characterised by  failure of eruption of permanent teeth with persistence of primary dentition–especially posterior teeth–in adulthood.

It is attributed to a malfunction of the eruptive mechanism itself, given that the eruption pathway has been cleared by bone resorption.

Molecular pathology Defects of PTH1R, which encodes parathyroid hormone receptor 1, cause failure of tooth eruption—primary. 

Synonyms Dental non-eruption, posterior openbite—familial, primary failure of eruption—non-syndromic, primary retention of teeth 

References http://www.uniprot.org/uniprot/Q03431

http://www.omim.org/entry/125350