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nobiletin image from New Medical Terms



A bitter antioxidant citrus flavonoid found in tangerines which is structurally similar to tangeretin.

Possible benefits

• Anti-acne  

• Anti-dementia

• Anti-atherogenic Inhibits deposition of lipid-laden macrophages in arterial walls, and reduces VLDL-triglyceride secretion. In fat-fed Ldlr−/− mice, it attenuates dyslipidemia by reducing VLDL-triglyceride (TG) secretion. It prevents hepatic TG accumulation, increases expression of Pgc1alpha and Cpt1alpha, and enhances fatty acid beta-oxidation, by a peroxisome proliferator–activated receptor (PPAR)-independent mechanism.

• Anti-diabetic Increases hepatic and peripheral insulin sensitivity and glucose tolerance

• Anti-inflammatory Acts as an antioxidant

• Anti-neoplastic Reduces proliferative activity in liver, stomach, prostate and colon cell lines

References Diabetes April 6, 2011, doi: 10.2337/db10-0589

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