A flavanone glycoside and major flavonoid in grapefruit, which gives grapefruit juice its tangy zest/bitter taste. It is metabolised to the flavanone naringenin.
Health benefits Antioxidant activity; lowers serum lipid levels
Alleged health benefits Reduced risk of cancer; reduced neurologic residua following stroke.
Pharmacologic effects Naringin inhibits certain cytochrome P450 enzymes–e.g., CYP3A4 and CYP1A2; it also inhibits VEGF* release
*Vascular endothelial growth factor, which induces angiogenesis