Definition A saturated dicarboxylic acid found in wheat, rye, and barley and in rancid oleic acid. It is produced industrially by the ozonolysis of oleic acid, and naturally by the yeast Malassezia furfur. It interferes with anerobic glycolysis and mitochondrial activity and has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis, possibly by inhibiting microbial protein synthesis, and thus has been used clinically for managing acne.
Synonym (CH2)7(CO2H)2, nonadioic acid
Definition AZELEX® cream is indicated for the topical treatment of mild-to-moderate inflammatory acne vulgaris. A topical gel, Finacea, is used to manage inflammatory papules and pustules of mild to moderate rosacea.
Definition Some anecdotal data vaguely suggest azelaic acid may have a therapeutic effect on lentigo maligna, a form of melanoma.
Most of the peer-reviewed studies on these benefits end in the late 1980s.
Reference International Journal of Clinical Practice 2002; 56:68-69