azelaic acid

Home » Classic Medicine » Chemistry » azelaic acid
azelaic acid2016-11-08T13:12:17+00:00

azelaic acid

CHEMISTRY

Definition A saturated dicarboxylic acid found in wheat, rye, and barley and in rancid oleic acid. It is produced industrially by the ozonolysis of oleic acid, and naturally by the yeast Malassezia furfur. It interferes with anerobic glycolysis and mitochondrial activity and has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis, possibly by inhibiting microbial protein synthesis, and thus has been used clinically for managing acne.

Synonym (CH2)7(CO2H)2, nonadioic acid 

DERMATOLOGY

Definition AZELEX® cream is indicated for the topical treatment of mild-to-moderate inflammatory acne vulgaris. A topical gel, Finacea, is used to manage inflammatory papules and pustules of mild to moderate rosacea.

Reference http://en.wikipedia.org/wiki/Azelaic_acid

FRINGE ONCOLOGY

Definition Some anecdotal data vaguely suggest azelaic acid may have a therapeutic effect on lentigo maligna, a form of melanoma.

Most of the peer-reviewed studies on these benefits end in the late 1980s.  

Reference International Journal of Clinical Practice 2002; 56:68-69  

 

Leave A Comment

This site uses Akismet to reduce spam. Learn how your comment data is processed.