A clinical trial that asked whether Zofenopril begun early post-anterior myocardial infarction improved short and long-term morbidity and mortality.
Primary endpoints Death or severe CHF during treatment period (6 weeks)
Secondary Endpoints Mild to moderate CHF at 6 weeks; nonfatal recurrent MI, angina; cumulative one year mortality
Conclusion Yes, if started within 24 hours and continued for 6 weeks
Abbreviation for Survival of Myocardial Infarction Long-term Evaluation: The Effects of the Angiotensin-Converting-Enzyme Inhibitor Zofenopril on Mortality and Morbidity after Anterior Myocardial Infarction
References N Engl J Med 1995;332:80-85
Am J Cardiol 1996;78:317-22