SMILE 

SMILE or Have a Nice Day!

CARDIOLOGY

A clinical trial that asked whether Zofenopril begun early post-anterior myocardial infarction improved short and long-term morbidity and mortality.

Primary endpoints Death or severe CHF during treatment period (6 weeks)

Secondary Endpoints Mild to moderate CHF at 6 weeks; nonfatal recurrent MI, angina; cumulative one year mortality

Conclusion Yes, if started within 24 hours and continued for 6 weeks

Abbreviation for Survival of Myocardial Infarction Long-term Evaluation: The Effects of the Angiotensin-Converting-Enzyme Inhibitor Zofenopril on Mortality and Morbidity after Anterior Myocardial Infarction 

References N Engl J Med 1995;332:80-85

Am J Cardiol 1996;78:317-22

PATHOLOGY

A term for an unstable form of reserve cell hyperplasia, which contains multiple mucus vacuoles within a mitotically active stratified epithelium with nuclear atypia. 

SMILE on a cervical biopsy is no reason to smile and should prompt levels on the tissue and embedding of more tissue, as it is associated with cervical intraepithelial neoplasia–CIN, cervical glandular intraepithelial neoplasia–CGIN, squamous cell carcinoma and adenocarcinoma. 

Abbreviation for Stratified Mucinous Intraepithelial LEsion