oxidatively modified low density lipoprotein

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oxidatively modified low density lipoprotein2016-11-04T15:09:20+00:00

oxidatively modified low density lipoprotein 

CARDIOLOGY, PHYSIOLOGY 

A chemical form of LDL (OxMLDL) produced by vascular endothelial cells, which is central to the formation of atherosclerotic plaques.

OxMLDL activates NF-kappa-B by increasing intracellular reactive oxygen production and inducing various pro-atherogenic cellular responses including vascular endothelial cell activation and dysfunction, reduction of nitric oxide (NO) release, pro-inflammatory responses, pro-oxidative conditions, monocyte adhesion and apoptosis. 

Reference J Biol Chem. 2012 Jul 6;287(28):23479-88.

doi: 10.1074/jbc.M111.320960

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