oxidatively modified low density lipoprotein
A chemical form of LDL (OxMLDL) produced by vascular endothelial cells, which is central to the formation of atherosclerotic plaques.
OxMLDL activates NF-kappa-B by increasing intracellular reactive oxygen production and inducing various pro-atherogenic cellular responses including vascular endothelial cell activation and dysfunction, reduction of nitric oxide (NO) release, pro-inflammatory responses, pro-oxidative conditions, monocyte adhesion and apoptosis.
Reference J Biol Chem. 2012 Jul 6;287(28):23479-88.