aldosterone escape

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aldosterone escape2016-11-15T15:32:46+00:00

aldosterone escape  

CARDIOLOGY, PATHOPHYSIOLOGY 

A phenomenon in which angiotensin II or aldosterone return to pretreatment levels despite the patients receiving continuous ACE* inhibition for hypertension.

*Angiotensin-converting-enzyme

Pathogenesis Uncertain; the phenomenon is attributed to non-ACE synthetic pathways which produce angiotensin II by action of serine proteases–e.g., chymase, cathepsin G and tissue plasminogen activator. 

Reference Cleveland Clinic J of Medicine 2013; 80:209-217  

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