-Found normally in the nasopharynx of healthy carriers.
-Significant human pathogen.(main cause of community acquired pneumonia and meningitis in children and the elderly, and of septicemia in HIV-infected persons.)
-Several other possible infections may occur including: acute sinusitis, otitis media, conjunctivitis, meningitis, bacteremia, sepsis, osteomyelitis, septic arthritis, endocarditis, peritonitis, pericarditis, cellulitis, and brain abscess. Also, one of the most common causes of bacterial meningitis in adults and young adults.
Important considerations: The choice of an agent should be based on local antimicrobial sensitivities, site of infection, cost, and comorbid conditions. Generally, the most common agents/regimens are listed first. Listed dosages may need to be adjusted for renal dysfunction.